Document Detail


Experiments with a reported anorexigenic tripeptide: pyro-Glu-His-Gly-OH.
MedLine Citation:
PMID:  538064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A newly described tripeptide, pyro-Glu-His-Gly-OH, which was reported to produce profound and long-term anorexia and weight loss in female mice, was initially tested in female rats. After total dose of either 8, 16, or 32 microgram SC of the peptide, administered across an eight day interval, there was no detectable effect on food intake, body weight, or estrous cycles of female rats. In a second study, we attempted to verify the anorexigenic potency of this peptide in mice. Total doses of 3.4 and 6.8 microgram, injected across a 20 day period, had no effect on the food intake or body weight of S/W albino female mice. Thus, the anorexigenic potency of pyro-Glu-His-Gly-OH has yet to be established.
Authors:
D M Nance; D H Coy; A J Kastin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  11     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants*
Body Weight / drug effects
Eating / drug effects
Female
Mice
Oligopeptides / pharmacology*
Pyrrolidonecarboxylic Acid / analogs & derivatives
Rats
Species Specificity
Time Factors
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Oligopeptides; 69275-10-1/pyroglutamyl-histidyl-glycine; 98-79-3/Pyrrolidonecarboxylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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