Document Detail

Experiments in marine biochemistry. Homarine metabolism in Penaeus duorarum.
MedLine Citation:
PMID:  1158889     Owner:  NLM     Status:  MEDLINE    
A fractionation procedure has been developed which permits the isolation of 1 to 2 mg of homarine from a single shrimp. This procedure was used to show that homarine is endogenously synthesized by Penaeus duorarum in the free unbound form, and to study the metabolic precursors involved. Injected DL-[14C]tryptophan was not converted to [14C]homarine. However, [6-14C]quinolinic acid, a known catabolite of tryptophan, is an effective precursor. [2-14C]Acetate and [U-14C]glycerol are effectively converted to [14C]homarine while [14C]bicarbonate is poorly utilized. The injection of L-[U-14C]aspartate resulted in labeled homarine, but the quantity converted was less than expected. Since [14C]glycerol is an effective precursor there is a possibility that quinolinic acid may be formed in P. duorarum by a condensation similar to that of glyceraldehyde 3-phosphate with aspartic acid or a closely related metabolite. It is suggested that decarboxylation of quinolinic acid gives rise to picolinic acid which is methylated to yield homarine. L-[methyl-14C]Methionine efficiently provides the N-methyl carbon presumably via S-adenosylmethionine.
E R Hall; S Gurin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  250     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-04     Completed Date:  1975-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6943-6     Citation Subset:  IM    
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MeSH Terms
Acetates / metabolism
Aspartic Acid / metabolism
Bicarbonates / metabolism
Chromatography, Ion Exchange
Glycerol / metabolism
Methionine / metabolism
Penaeidae / metabolism*
Picolinic Acids / isolation & purification,  metabolism*
Quinolinic Acids / metabolism
Tryptophan / metabolism
Reg. No./Substance:
0/Acetates; 0/Bicarbonates; 0/Picolinic Acids; 0/Quinolinic Acids; 56-81-5/Glycerol; 56-84-8/Aspartic Acid; 63-68-3/Methionine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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