Document Detail


Experimental verification and theoretical prediction of cartilage interstitial fluid pressurization at an impermeable contact interface in confined compression.
MedLine Citation:
PMID:  9840758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interstitial fluid pressurization has long been hypothesized to play a fundamental role in the load support mechanism and frictional response of articular cartilage. However, to date, few experimental studies have been performed to verify this hypothesis from direct measurements. The first objective of this study was to investigate experimentally the hypothesis that cartilage interstitial fluid pressurization does support the great majority of the applied load, in the testing configurations of confined compression creep and stress relaxation. The second objective was to investigate the hypothesis that the experimentally observed interstitial fluid pressurization could also be predicted using the linear biphasic theory of Mow et al. (J. Biomech. Engng ASME, 102, 73-84, 1980). Fourteen bovine cartilage samples were tested in a confined compression chamber fitted with a microchip piezoresistive transducer to measure interstitial fluid pressure, while simultaneously measuring (during stress relaxation) or prescribing (during creep) the total stress. It was found that interstitial fluid pressure supported more than 90% of the total stress for durations as long as 725 +/- 248 s during stress relaxation (mean +/- S.D., n = 7), and 404 +/- 229 s during creep (n = 7). When comparing experimental measurements of the time-varying interstitial fluid pressure against predictions from the linear biphasic theory, nonlinear coefficients of determination r2 = 0.871 +/- 0.086 (stress relaxation) and r2 = 0.941 +/- 0.061 (creep) were found. The results of this study provide some of the most direct evidence to date that interstitial fluid pressurization plays a fundamental role in cartilage mechanics; they also indicate that the mechanism of fluid load support in cartilage can be properly predicted from theory.
Authors:
M A Soltz; G A Ateshian
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomechanics     Volume:  31     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  927-34     Citation Subset:  IM; S    
Affiliation:
Department of Mechanical Engineering, Columbia University, New York, NY 10027, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Cartilage, Articular / physiology
Cattle
Differential Threshold
Extracellular Space / physiology*
Models, Biological*
Pressure
Stress, Mechanical
Time Factors
Grant Support
ID/Acronym/Agency:
R29 AR-43628/AR/NIAMS NIH HHS
Comments/Corrections
Erratum In:
J Biomech. 2006;39(3):594

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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