Document Detail

Experimental vascular graft for liver transplantation.
MedLine Citation:
PMID:  14680065     Owner:  NLM     Status:  MEDLINE    
Hepatic artery thrombosis is a major cause of graft failure in liver transplantation. Use of donor interponates are common, but results are controversial because of necrosis or thrombosis after rejection. Reperfusion injury, hypoxia and free radical production determinate the survival. The aim of the study was to create an 'ideal' arterial interponate. Autologous, tubular graft lined with mesothelial cells, prepared from the posterior rectus fascia sheath, was used for iliac artery replacement in eight mongrel dogs for six months under immunosuppression. Patency rate was followed by Doppler ultrasound. Eight grafts remained patent and another two are patent after one year. The patency rate was good (median Doppler flow: 370 cm/sec) and there was no necrosis, thrombosis or aneurysmatic formation. The grafts showed viable morphology with neoangiogenesis, appearance of elastin, smooth muscle and endothelial cells. Electron microscopy showed intact mitochondrial structures without signs of hypoxia. Tissue oxygenation was good in all cases with normal (< 30 ng/ml) myeloperoxidase production. In conclusion, this autologous graft presents good long-term patency rate. Viability, arterialisation and low thrombogenicity are prognostic factors indicating usability of the graft in the clinical practice without the risk of rejection. Further investigations such as cell cultures and standardisation are necessary.
L Kóbori; T Németh; B Nemes; G Dallos; P Sótonyi; I Fehérvári; A Patonai; M J H Slooff; J Járay; K P De Jong
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Acta veterinaria Hungarica     Volume:  51     ISSN:  0236-6290     ISO Abbreviation:  Acta Vet. Hung.     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-18     Completed Date:  2004-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406376     Medline TA:  Acta Vet Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  529-37     Citation Subset:  IM    
Transplantation and Surgical Department, Semmelweis University, H-1082 Budapest, Baross u. 23-25, Hungary.
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MeSH Terms
Iliac Artery / transplantation*
Liver Transplantation*
Vascular Patency*

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