Document Detail

Experimental uraemia with associated plasma amino acid abnormalities but without retarded food intake and weight gain.
MedLine Citation:
PMID:  2797343     Owner:  NLM     Status:  MEDLINE    
A rat model of moderate uraemia is described in which uraemic animals attain normal food intake and weight gain. Despite the low levels of the induced uraemia, which has been well defined, changes in plasma amino acid concentrations associated with experimental uraemia still occur. It appears from this study that a reduction in food intake is not a major factor in the aetiology of the plasma amino acid changes seen in uraemia and that the model may prove useful in future studies of experimental chronic renal failure.
D J Haines; C H Swan; J R Green; J F Woodley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  53     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Department of Postgraduate Medicine, North Staffordshire Medical Institute, Hartshill, Stoke-on-Trent, UK.
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MeSH Terms
Amino Acids / blood*
Creatinine / blood
Rats, Inbred Strains
Urea / blood
Uremia / etiology,  physiopathology*
Weight Gain*
Reg. No./Substance:
0/Amino Acids; 57-13-6/Urea; 60-27-5/Creatinine

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