| Experimental transient exudative retinal detachment in the rat. | |
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MedLine Citation:
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PMID: 8085967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To establish a new model of exudative retinal detachment in the rat. METHODS: Photothrombosis was produced in a single retinal vein using direct treatment with a dye laser operating in the yellow wavelength (577 nm). Control eyes received identical laser applications, but treatment was placed alongside the vessel and photothrombosis was not produced. Eyes were examined at intervals during the subsequent week with ophthalmoscopy, photography, fluorescein angiography, and light microscopy. RESULTS: In 13 (41%) of 32 eyes with photothrombosis, bullous retinal detachments developed 1 day after laser treatment, and continued occlusion of the vein was confirmed with fluorescein angiography. Detachments persisted for 2 to 4 days and spontaneously resolved; resolution coincided with restored venous patency at 5 to 7 days. None of the 20 control eyes developed bullous detachments (P < .005). CONCLUSIONS: Laser photothrombosis in the rat offers a simple and accessible model of transient exudative retinal detachment without the need for exogenous chromophores. |
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Authors:
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P G Theodosiadis; R S Moulton; A W Walsh; E S Gragoudas; D J D'Amico |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of ophthalmology Volume: 112 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-10-13 Completed Date: 1994-10-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1236-42 Citation Subset: AIM; IM |
Affiliation:
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Retina Service, Massachusetts Eye and Ear Infirmary, Boston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Exudates and Transudates Fluorescein Angiography Fundus Oculi Laser Therapy Male Rats Retinal Detachment / etiology, pathology* Retinal Vein / surgery Retinal Vein Occlusion / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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