Document Detail


Experimental therapy approaches for ischemic stroke.
MedLine Citation:
PMID:  23015194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In Germany, as in most other industrialized countries, ischemic stroke is the leading cause of disability and the third leading cause of death. As the incidence of ischemic stroke increases with age it is expected that this problem will become even more urgent in an aging society. Despite significant research efforts on the clinical as well as on the experimental level, treatment of ischemic stroke is still based on general intensive care measures and on reperfusion therapy with recombinant tissue plasminogen activator (rtPA); however, rtPA is not suitable for a wide range of patients and is restricted to a therapeutic window of 4.5 h due to an increasing risk of bleeding. Accordingly, novel therapeutic options for ischemic stroke are urgently need. The current review discusses novel experimental therapeutic principles for ischemic stroke which may have clinical potential. The main topics are neuroprotection and strategies addressing the immune system.
Authors:
C Kleinschnitz; N Plesnila
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Der Nervenarzt     Volume:  -     ISSN:  1433-0407     ISO Abbreviation:  Nervenarzt     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400773     Medline TA:  Nervenarzt     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Neurologische Klinik und Poliklinik, Universitätsklinik Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland, christoph.kleinschnitz@uni-wuerzburg.de.
Vernacular Title:
Experimentelle Ansätze zur Therapie des ischämischen Schlaganfalls.
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