| Experimental therapeutic approaches to adenocarcinoma: the potential of tumor cells engineered to express MHC class II molecules combined with naked DNA interleukin-12 gene transfer. | |
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MedLine Citation:
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PMID: 18035537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously shown that TS/A murine mammary adenocarcinoma cells, induced to express high surface expression of MHC class II molecules by stable transfection of CIITA, resulted in high rate (92%) of tumor rejection and tumor immunity to subsequent homologous tumor challenges. The immunological basis of tumor response is based on tumor-specific CD4(+) T helper type 1 (Th1) in the priming phase and tumor-specific CD8(+) T cells as the major effector cells. IL-12 is the crucial cytokine that drives Th1 polarization in conjunction with inducing strong cellular-based immune responses. We have previously shown in the same tumor model that a naked DNA IL-12 gene transfer was effective in preventing tumor angiogenesis in an immunopreventive approach when administrated at least 2 days prior to the tumor inoculation. Here we indicate that the combination of the two approaches in immunotherapy of established tumors is efficacious in delaying tumor growth but not in completely eradicating the tumor. |
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Authors:
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Lorenzo Mortara; Luca Giuliani; Andrea De Lerma Barbaro; Roberto S Accolla; Douglas M Noonan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-11-26 |
Journal Detail:
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Title: Surgical oncology Volume: 16 Suppl 1 ISSN: 0960-7404 ISO Abbreviation: Surg Oncol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-04-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208188 Medline TA: Surg Oncol Country: Netherlands |
Other Details:
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Languages: eng Pagination: S33-6 Citation Subset: IM |
Affiliation:
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Department of Clinical and Biological Sciences, School of Medicine, University of Insubria, Via Ottorino Rossi, 9-21100 Varese, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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immunology* Animals Gene Therapy Genes, MHC Class II Humans Immunotherapy, Adoptive Interleukin-12 / genetics, metabolism Mammary Neoplasms, Animal / immunology* Nuclear Proteins / biosynthesis, immunology* Trans-Activators / biosynthesis, immunology* Transfection |
| Chemical | |
Reg. No./Substance:
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0/MHC class II transactivator protein; 0/Nuclear Proteins; 0/Trans-Activators; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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