| Experimental study of verapamil on the relaxation of isolated human corpus cavernosum tissues. | |
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MedLine Citation:
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PMID: 16491271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the relaxant effect of verapamil on human corpus cavernosum in vitro and to assess the drug's potential as a treatment for erectile dysfunction (ED). METHODS: Preparations of the human corpus cavernosum were obtained from recently deceased young men who had had normal erectile function. The isometric tension and detailed curves were recorded when contractions induced by 10 micromol/L phenylephrine were reduced by different doses of verapamil or the vehicle control (sterile water). The tension of human corpus cavernosum preparations are described as a percentage of their top tension before adding verapamil or the vehicle. ANOVA and least significant difference tests were used for statistical analysis. RESULTS: Doses of 1 micromol/L, 10 micromol/L and 100 micromol/L verapamil resulted in relaxation of (35.28+/-7.96)%, (55.91+/-6.41)%, (85.68+/-4.16)% after 30 min, respectively. The vehicle control at the same time point produced relaxation of (-0.06+/-10.57)% (P<0.05). CONCLUSION: Verapamil is significantly effective in relaxing normal human corpus cavernous smooth muscle induced by phenylephrine in vitro and the relaxant effect depends on the concentration of verapamil. |
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Authors:
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Lu-Lin Ma; Yu-Qing Liu; Wen-Hao Tang; Lian-Ming Zhao; Hui Jiang |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Asian journal of andrology Volume: 8 ISSN: 1008-682X ISO Abbreviation: Asian J. Androl. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-05-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: China |
Other Details:
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Languages: eng Pagination: 195-8 Citation Subset: IM |
Affiliation:
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Department of Urology, Third Affiliated Hospital, Peking University, Beijing 100083, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Male Muscle Relaxation / drug effects* Muscle, Smooth, Vascular / drug effects*, physiology Penis / drug effects, physiology Verapamil / pharmacology* |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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