Document Detail

Experimental study of thallium 201 redistribution in transient myocardial ischemia.
MedLine Citation:
PMID:  7120444     Owner:  NLM     Status:  MEDLINE    
The influence of differential washout on the redistribution phenomenon of thallium 201 chloride deposited in ischemic myocardium was investigated. Two groups of dogs had serial scintigraphic images and tissue counting performed. The first group had ischemia produced prior to the injection of the thallium and, following the control image after production of ischemia, the occlusion was released and serial images obtained over a three-hour period. The second group received thallium initially and after a control scintigraph was taken, ischemia was created and maintained for three hours via transthoracic ligature. Activity distribution was followed by serial images. Thallium content of ischemic areas was compared to the normal area by computer assisted data analysis. Tissues from the ischemic and normal areas from both groups were obtained after the serial images and counted. In the first group, prompt redistribution of activity into the ischemic areas was seen within 30 minutes of releasing the occlusion and was verified by tissue counting. Neither scintigraphic image changes nor tissue uptake differences were observed in the second group. The restoration of blood flow and consequently increased avidity for thallium probably accounted for the redistribution seen in the first group as there appeared to be no differential washout of activity in the second group from either the ischemic or normal areas to contribute to the redistribution phenomenon.
T Tanaka; A K Mandal; D Q Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  74     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / radionuclide imaging*
Radioisotopes / analysis*
Thallium / analysis*
Reg. No./Substance:
0/Radioisotopes; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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