Document Detail

Experimental study of quantitative assessment of left ventricular mass with contrast enhanced real-time three-dimensional echocardiography.
MedLine Citation:
PMID:  14750411     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the feasibility and accuracy of measurement of left ventricular mass with intravenous contrast enhanced real-time three-dimensional (RT3D) echocardiography in the experimental setting. METHODS: RT3D echocardiography was performed in 13 open-chest mongrel dogs before and after intravenous infusion of a perfluorocarbon contrast agent. Left ventricular myocardium volume was measured according to the apical four-plane method provided by TomTec 4D cardio-View RT1.0 software, then the left ventricular mass was calculated as the myocardial volume multiplied by the relative density of myocardium. Correlative analysis and paired t-test were performed between left ventricular mass obtained from RT3D echocardiography and the anatomic measurements. RESULTS: Anatomic measurement of total left ventricular mass was 55.6 +/- 9.3 g, whereas RT3D echocardiographic calculation of left ventricular mass before and after intravenous perfluorocarbon contrast agent was 57.5 +/- 11.4 and 55.5 +/- 9.3 g, respectively. A significant correlation was observed between the RT3D echocardiographic estimates of total left ventricular mass and the corresponding anatomic measurements (r = 0.95). A strong correlation was found between RT3D echocardiographic estimates of left ventricular mass with perfluorocarbon contrast and the anatomic results (r = 0.99). Analysis of intraobserver and interobserver variability showed strong indexes of agreement in the measurement of left ventricular mass with pre and post-contrast RT3D echocardiography. CONCLUSIONS: Measurements of left ventricular mass derived from RT3D echocardiography with and without intravenous contrast showed a significant correlation with the anatomic results. Contrast enhanced RT3D echocardiography permitted better visualization of the endocardial border, which would provide a more accurate and reliable means of determining left ventricular myocardial mass in the experimental setting.
Lei Zhuang; Xin-Fang Wang; Ming-Xing Xie; Li-Xin Chen; Hong-Wen Fei; Ying Yang; Jing Wang; Run-Qing Huang; Ou-Di Chen; Liang-Yu Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiology     Volume:  43     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Department of Echocardiography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, PR China.
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MeSH Terms
Contrast Media
Echocardiography, Three-Dimensional* / standards
Feasibility Studies
Fluorocarbons / diagnostic use
Heart Ventricles / anatomy & histology,  ultrasonography*
Observer Variation
Stroke Volume
Ventricular Function, Left* / physiology
Ventricular Remodeling*
Reg. No./Substance:
0/Contrast Media; 0/Fluorocarbons

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