| Experimental study of a novel method of cardiopulmonary resuscitation using a combination of percutaneous cardiopulmonary support and liposome-encapsulated hemoglobin (TRM645). | |
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MedLine Citation:
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PMID: 18766206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Percutaneous cardiopulmonary support (PCPS) has been applied for cardiopulmonary arrest (CPA). We have developed a novel method of cardiopulmonary resuscitation using PCPS combined with liposome-encapsulated hemoglobin (TRM645) to improve oxygen delivery to vital organs. Ventricular fibrillation was electrically induced to an adult goat for 10 min. Next, PCPS (30 ml/kg/min, V/Q: 1) was performed for 20 min. Then, external defibrillation was attempted and observed for 120 min. The TRM group (n5) was filled with 300 mL of TRM645 for the PCPS circuit. The control group (n5) was filled with the same volume of saline. The delivery of oxygen (DO2) and oxygen consumption (VO2) decreased markedly by PCPS after CPA, compared to the preoperative values. DO2 was kept at a constant level during PCPS in both groups, but VO2 slowly decreased at 5, 10, and 15 min of PCPS in the control groups, demonstrating that systemic oxygen metabolism decreased with time. In contrast, the decreases in VO2 were small in the TRM group at 5, 10, and 15 min of PCPS, demonstrating that TRM645 continuously maintained systemic oxygen consumption even at a low flow rate. AST and LDH in the TRM group were lower than the control. There were significant differences at 120 min after the restoration of spontaneous circulation (p<0.05). |
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Authors:
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Kei Ota; Toshihide Mizuno; Eisuke Tatsumi; Nobumasa Katagiri; Yoshiyuki Taenaka; Takanobu Ishizuka; Yoshitaka Ogata; Yoshihito Ujike |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta medica Okayama Volume: 62 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-09-03 Completed Date: 2008-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: Japan |
Other Details:
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Languages: eng Pagination: 235-9 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. ZUB07316@nifty.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Resuscitation / methods* Extracorporeal Circulation* / instrumentation, methods, utilization Goats Heart Arrest / therapy* Hemoglobins / administration & dosage*, chemistry*, therapeutic use* Humans Liposomes / chemistry, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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