Document Detail


Experimental study of nonpulsatile flow perfusion and structural remodeling of pulmonary microcirculation vessels.
MedLine Citation:
PMID:  21110269     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the study was to investigate whether functional changes and structural remodeling occurs in the microvascular bed of the pulmonary circulation under nonpulsatile flow perfusion.
MATERIALS AND METHODS: An animal model of unilateral nonpulsatile flow in the right lung was established in dogs. Streptavidin-biotin enzyme complex (SP method) was used to detect the expression of endothelial nitric oxide synthase (eNOS) in vascular endothelial cells and the apoptosis-related protein Fas in smooth muscle cells of the pulmonary artery of both lungs, and structural changes of the arterioles in the capillary bed of both lungs were observed under light microscope.
RESULTS: eNOS expression in right lung arterioles with nonpulsatile flow perfusion was significantly lower than in the left lung (10,846.7 ± 177.8 vs. 13,136.1 ± 189.6; T = 2.24, P < 0.05). Expression of the apoptosis-related protein Fas in smooth muscle cells of the arteriole of the right lung was significantly higher than in the left lung (14,254.1 ± 217.1 vs. 11,976.7 ± 195.7; T = 2.16, P < 0.05). Image analysis of pulmonary arterioles showed that the ratio of vascular wall thickness and the external vessel diameter (13.64% ± 12.8% vs. 14.96% ± 13.1%) and the ratio of vascular wall area and the total vessel area (46.4% ± 11.7% vs. 47.8% ± 12.2%) of the right lung were significantly lower than in the left lung.
CONCLUSIONS: Long-term nonpulsatile flow perfusion of the Fontan circulation can decrease the synthesis of eNOS in endothelial cells of the pulmonary vessels, increase the apoptosis of smooth muscle cells of the arteriole wall, and lead to arterial venous conversion and pulmonary vessel remodeling.
Authors:
Y Zongtao; W Huishan; W Zengwei; Z Hongyu; F Minhua; Li Xinmin; Z Nanbin; H Hongguang
Related Documents :
18810339 - Rhombencephalosynapsis: association with single umbilical artery.
21183769 - Novel use of the heartrail catheter as a thrombectomy device.
21881379 - Preoperative computed tomographic diagnosis of an aortocaval fistula associated with an...
18986639 - Incidence and risk factors for surgical intervention after uterine artery embolization.
8896299 - Indirect measurement of blood pressure without a cuff.
21611029 - Helical ct angiography of fenestrated stent grafting of abdominal aortic aneurysms.
24999109 - The art of cerebral aneurysms: three decades of postoperative drawings.
16099689 - Mr imaging-guided percutaneous tumor ablation.
21613319 - Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns ...
Publication Detail:
Type:  Journal Article     Date:  2010-11-25
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  58     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  468-72     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Department of Cardiovascular Surgery, Shenyang Northern Hospital, Shenyang, China. yzt1210@live.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heparin-induced thrombocytopenia type II after cardiac surgery: predictors and outcome.
Next Document:  Benign posterior mediastinal neurogenic tumors: results of a comparative study into video-assisted t...