Document Detail

Experimental study of the histocompatibility of covered expandable metallic stents in the trachea.
MedLine Citation:
PMID:  9674456     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To evaluate the histocompatibility of four different materials used to cover expandable metallic stents. DESIGN: Prospective, randomized, unblinded study. SETTING: Animal research laboratory of Kurume University. PATIENTS OR PARTICIPANTS: Twenty 12- to 18-kg mongrel dogs. INTERVENTIONS: Handmade Gianturco-type stents with six bends, 20 mm in length, and 15 to 20 mm in diameter were covered using four different materials: polypropylene mesh, silicone-coated mesh, polyester mesh, and ePTFE. Covered stents were inserted into the trachea after i.v. anesthesia. Five animals were used in each group. MEASUREMENTS AND RESULTS: Postinsertion status was observed using clinical and bronchoscopy measures 7, 14, 28, and 56 days after intervention. Eight weeks after stent insertion, the tracheal specimens were studied pathologically. A scoring system was used to evaluate the histocompatibility of covered stents in each study group. The mean of clinical scores in the polypropylene group was 1.84+/-0.36, which was significantly higher than those in the groups of silicone, polyester, and ePTFE. The means of histopathologic scores in the polypropylene group and the silicone group were 1.60+/-0.55, which were significantly higher than those in groups of polyester and ePTFE. CONCLUSIONS: Polypropylene mesh cover was more suitable than silicone-coated mesh, polyester mesh, and ePTFE because of its excellent histocompatibility.
M Mitsuoka; A Hayashi; S Takamori; K Tayama; K Shirouzu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  114     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-05     Completed Date:  1998-08-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  AIM; IM    
The Department of Surgery, Kurume University, School of Medicine, Fukuoka, Japan.
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MeSH Terms
Anesthesia, Intravenous
Biocompatible Materials* / adverse effects
Cough / etiology
Epithelium / pathology
Equipment Design
Granulation Tissue / pathology
Hemorrhage / etiology
Intubation, Intratracheal
Polyesters / adverse effects
Polypropylenes / adverse effects
Polytetrafluoroethylene / adverse effects
Prospective Studies
Random Allocation
Silicones / adverse effects
Stainless Steel
Stents* / adverse effects
Surface Properties
Surgical Mesh*
Tracheitis / etiology
Reg. No./Substance:
0/Biocompatible Materials; 0/Polyesters; 0/Polypropylenes; 0/Silicones; 12597-68-1/Stainless Steel; 9002-84-0/Polytetrafluoroethylene

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