| Experimental study of hepatic artery embolization: evaluation of various embolic materials. | |
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MedLine Citation:
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PMID: 2827239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcatheter arterial embolization was performed in a group of rabbits bearing VX2 tumor in the liver by injecting gelatin sponge (GS) with or without an anticancer agent (ACA) or Lipiodol with or without ACA. The antitumor effects as evaluated by tumor size and histological examination revealed that GS with or without ACA was most effective, followed in order by Lipiodol-ACA, aqueous solution of ACA and Lipiodol alone. On the other hand, severe normal tissue damage (necrosis of the liver and gallbladder) with elevation of plasma GOT, GPT, and LDH levels was more commonly observed in GS with or without ACA. Pharmacological analysis of plasma and tissue revealed that the antitumor effect of Lipiodol-ACA was due to prolonged release of ACA in addition to the embolization effect of Lipiodol, while the chemotherapeutic role of ACA was of little importance in GS-ACA. |
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Authors:
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Y Yamashita; M Takahashi; S Fukushima; M Nishida; M Nakano |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Radiation medicine Volume: 5 ISSN: 0288-2043 ISO Abbreviation: Radiat Med Publication Date: 1987 May-Jun |
Date Detail:
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Created Date: 1988-01-25 Completed Date: 1988-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8412264 Medline TA: Radiat Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 75-82 Citation Subset: IM |
Affiliation:
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Department of Radiology, Kumamoto University, School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Aspartate Aminotransferases / blood Doxorubicin / therapeutic use* Embolization, Therapeutic* Gelatin Sponge, Absorbable / therapeutic use* Hepatic Artery Iodized Oil / therapeutic use* L-Lactate Dehydrogenase / blood Liver Neoplasms, Experimental / therapy* Neoplasm Transplantation Rabbits |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin; 8001-40-9/Iodized Oil; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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