| Experimental study of cryopreserved allogeneic transfer of vessel: preliminary report. | |
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MedLine Citation:
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PMID: 8133771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has long been known that the antigenicity of tissues is depressed when they are kept at a very low temperature. In this study, Lewis rats and Brown Norway (B.N.) rats were used because these species are significantly dissimilar at the major histocompatibility complex (MHC) Femoral arteries were harvested from Lewis rats, frozen while lowering the temperature in a stepwise fashion to -70 degrees C. After three weeks of cryogenic storage, the arteries were transplanted into Lewis and B.N. rats. At various times from the first to the twelfth week after surgery, grafted vessels were observed, and pathological and electron microscopic studies were carried out. The vessels were found to be in good condition at the end of the 12 week observation period. These results strongly suggest that prolonged cryopreservation of vessels makes allotransplantation without immunosuppression possible. |
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Authors:
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M Takeishi; Y Hirase; T Kojima |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microsurgery Volume: 15 ISSN: 0738-1085 ISO Abbreviation: Microsurgery Publication Date: 1994 |
Date Detail:
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Created Date: 1994-04-20 Completed Date: 1994-04-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8309230 Medline TA: Microsurgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 55-62 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Jikei University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / immunology, transplantation*, ultrastructure Cryopreservation* Immunosuppression Male Rats Rats, Inbred BN Rats, Inbred Lew Tissue Preservation / methods* Transplantation, Homologous Vascular Patency |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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