Document Detail


Experimental study and constitutive modelling of the passive mechanical properties of the porcine carotid artery and its relation to histological analysis: Implications in animal cardiovascular device trials.
MedLine Citation:
PMID:  21371929     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present study focusses on the determination, comparison and constitutive modelling of the passive mechanical properties of the swine carotid artery over very long stretches in both proximal and distal regions. Special attention is paid to the histological and mechanical variations of these properties depending on the proximity to the heart. The results can have clinical relevance, especially in the research field of intravascular device design. Before the final clinical trials on humans, research in the vascular area is conducted on animal models, swine being the most common due to the similarities between the human and swine cardiovascular systems as well as the fact that the swine size is suitable for testing devices, in this case endovascular carotid systems. The design of devices usually involves numerical techniques, and an important feature is the appropriate modelling of the mechanical properties of the vessel. Fourteen carotid swine arteries were harvested just after sacrifice and cyclic uniaxial tension tests in longitudinal and circumferential directions were performed for distal and proximal samples. The stress-stretch curves obtained were fitted with a hyperelastic anisotropic model. Stress-free configuration states were also analyzed. Finally, human and swine samples were processed in a histological laboratory and images were used to quantify their microconstituents. The statistical analysis revealed significant differences between the mechanical behavior of proximal and distal locations in the circumferential but not in the longitudinal direction. Circumferential direction samples show clear differences both in residual stretches and tensile curves between the two locations, while the features of longitudinal specimens are independent of the axial position. The statistical analysis provides significant evidence of changes depending on the position of the sample, mainly in elastin and SMC quantification.
Authors:
A García; E Peña; A Laborda; F Lostalé; M A De Gregorio; M Doblaré; M A Martínez
Related Documents :
22611859 - Is catchment productivity a useful predictor of taxa richness in lake plankton communit...
22358159 - Projection approach to complexity reduction in tomographic alignment of extremely large...
15212919 - On the implications of interpreting the stability index: a spine example.
22806579 - Datapipeline: automated importing and fitting of large amounts of biophysical data.
21356839 - A test of the markov model of evolution in proteins.
21511139 - A comparison of artificial neural networks and partial least squares modelling for the ...
6509119 - Stabilization of hebbian neural nets by inhibitory learning.
1302669 - Prist-2: a graphic user interface based tool for the development of medical software.
10993419 - A comparative evaluation of three accelerometry-based physical activity monitors.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Medical engineering & physics     Volume:  -     ISSN:  1873-4030     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 IPEM. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Group of Structural Mechanics and Materials Modelling, Aragón Institute of Engineering Research, University of Zaragoza, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Aragón Institute of Health Sciences (IACS), Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role o...
Next Document:  A spatial analysis of the physical and social environmental correlates of discarded needles.