Document Detail

Experimental study of combination of extraaortic balloon counterpulsation and ventricular assist cup to acute heart failure in dogs.
MedLine Citation:
PMID:  9152489     Owner:  NLM     Status:  MEDLINE    
The goal of this study is to evaluate the applicability and effectiveness of combination support of the extraaortic balloon (EAB) and the ventricular assist cup (VAC) to the acute heart failure model. Under general anesthesia, 10 adult dogs were used. Through the median sternotomy, EAB was placed around the ascending aorta and VAC in the pericardial cavity. After heart failure was induced by administration of propranolol, the on-off tests of devices were done as follows. Only EAB was used, and only VAC was used and both devices were used. Regional blood flows (RBFs) of both ventricles, liver kidneys, and brain were measured by colored microsphere technique. Hemodynamic parameters were also measured. In heart failure model, cardiac output (CO) decreased to 66% of control value. In the group assisted by EAB, aortic peak-diastolic pressure and RBFs of both ventricle and brain increased significantly. In the group assisted by VAC, CO and RBFs of all but the left ventricle significantly increased. In the group assisted by EAB and VAC, aortic peak-diastolic pressure, CO, and all five RBFs significantly increased. These results suggest the combination of EAB and VAC is applicable and effective and would be a promising implantable device for the chronic heart failure.
A Mitsumaru; R Yozu; Y Inoue; S Tanaka; H Yoshito; K Kanda; Y Tsutsui; N Tsutsui; S Kawada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  43     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Department of Surgery, Keio University, Tokyo, Japan.
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MeSH Terms
Acute Disease
Counterpulsation / methods*
Disease Models, Animal
Evaluation Studies as Topic
Heart Failure / physiopathology,  therapy*
Heart-Assist Devices*
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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