Document Detail

Experimental study on the bilirubin metabolism after major hepatectomy: alterations in the proportions of bile bilirubin subfractions.
MedLine Citation:
PMID:  10068528     Owner:  NLM     Status:  MEDLINE    
Bilirubin metabolism after major hepatectomy was investigated experimentally using rats. After a 70% and an 80% hepatectomy, proportions of bilirubin diglucuronide (BDG) decreased, and reversely, those of bilirubin monoglucuronide (BMG) increased. These changes were even more remarkable after an 80% hepatectomy. Parallel to the decrease in the proportions of BDG, the concentrations of uridine diphosphoglucuronic acid (UDP-GA) in the remnant liver decreased, and there was a significant correlation between the changes in BDG and UDP-GA. Although UDP-glucuronyltransferase (UDP-GT) activity and energy charge of the remnant liver also decreased after surgery, these decreases were mild and returned to the control level earlier than BDG. And there was no significant correlation between the changes in BDG and those in UDP-GT activity and energy charge. In this study, the decrease of the proportions of BDG in the bile juice was long term after partial hepatectomy and the period of the decrease became longer according to the augmentation of the volume of the hepatectomized liver. We clarified that the process of the UDP-GA production was inhibited after hepatectomy and the decrease of the proportions of BDG was derived from a deficiency of substrate of the glucuronidation, UDP-GA.
Y Igarashi; S Ishiyama; M Urayama; H Kuzu; A Fuse; M Tsukamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  82     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-25     Completed Date:  1999-03-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
The First Department of Surgery, Yamagata University, Yamagata, Japan.
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MeSH Terms
Bile / metabolism*
Bilirubin / analogs & derivatives,  metabolism*
Energy Metabolism
Glucuronosyltransferase / metabolism
Hepatectomy / adverse effects*
Liver / metabolism
Rats, Sprague-Dawley
Time Factors
Uridine Diphosphate Glucuronic Acid / metabolism
Reg. No./Substance:
17459-92-6/bilirubin diglucuronide; 2616-64-0/Uridine Diphosphate Glucuronic Acid; 27071-67-6/bilirubin glucuronate; 635-65-4/Bilirubin; EC

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