Document Detail


Experimental studies on the toxicity of Ferula communis in the rat.
MedLine Citation:
PMID:  3363223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study of two chemically characterized varieties of Ferula communis showed that only plants containing prenylated coumarins are toxic. The contrasting data on the toxicity of Ferula communis most probably raised from the use of chemically uncharacterized specimens. Among the constituents of the toxic variety, both ferulenol, a 4-hydroxycoumarin derivative, and ferprenin, a pyrane (3,2-c) coumarin derivative, affected blood clotting. No hepatotoxicity was elicited by these two compounds.
Authors:
M Aragno; S Tagliapietra; G M Nano; G Ugazio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  59     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-402     Citation Subset:  IM    
Affiliation:
Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Patologia Ambientale, Torino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coumarins / analysis,  toxicity*
Ferula / analysis*
Male
Plants, Medicinal*
Plants, Toxic / analysis*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Coumarins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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