| Experimental studies on sick sinus syndrome: relationship of extent of right atrial lesions to subsidiary pacemaker shift and its function. | |
| | |
MedLine Citation:
|
PMID: 6340449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An area where the sinus node was located in 36 dogs was defined as the "SN-area." Five to 7 days after cauterization of the SN-area, a subsidiary pacemaker remained in the SN-area in seven (group S) and shifted to outside the SN-area in 14 dogs (group E). The SN-area in group S had escaped complete destruction, but that in group E was destroyed completely. Heart rate in group S and group E was 154.0 +/- 27.1 and 107.6 +/- 16.8 beats/min (p less than 0.001), respectively. Maximum duration of asystole after overdrive (maxDAO) in group S and group E was 656.7 +/- 260.2 and 2470.2 +/- 2271.6 msec (p less than 0.01), respectively. Propranolol (0.2 mg/kg intravenously) decreased heart rate in group S and group E to 88.3 +/- 7.9 and 71.7 +/- 8.7% (p less than 0.001), and prolonged maxDAO to 140.1 +/- 28.1 and 492.7 +/- 591.4% (p less than 0.025), respectively. It is concluded that the rate and stability of subsidiary pacemakers after cauterization of the sinus node have a close relationship with their location in the right atrium, which is dependent on the extent of lesions in the SN-area. Sympathetic tone played a significant role in maintaining these functions in group E. |
| | |
Authors:
|
S Ishikawa; K Sawada; Y Tanahashi; J Tsuzuki; M Hattori; R Kato; I Sotohata; J Toyama |
Related Documents
:
|
6658849 - Effect of ovarian steroids on uptake of radioactive amino acids by brain tissues. 23234939 - The discovery of s/gsk1265744: a carbamoyl pyridone hiv-1 integrase inhibitor. 17263269 - The impact of operative fluids on the prevention of postoperative anesthetic complicati... 17981079 - Study on potential effects of "902-mhz gsm-type wireless communication signals" on dmba... 18192689 - Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols in... 11329099 - Steady-state pharmacokinetics of high-dose diltiazem hydrochloride (cardizem cd) admini... 22045039 - Efficacy and tolerability of extended-release quetiapine fumarate monotherapy in the ac... 21388069 - Metastatic paraganglioma and treatment with sunitinib: a case report. 21510179 - Potential of ozone as a fumigant to control pests in honey bee (hymenoptera: apidae) hi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 105 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1983 Apr |
Date Detail:
|
Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2006-02-27 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 593-602 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Pacing, Artificial Dogs Electrocardiography Female Heart Arrest / physiopathology Heart Atria / pathology Heart Conduction System / pathology, physiopathology* Heart Rate* / drug effects Male Propranolol / pharmacology Sick Sinus Syndrome / pathology*, physiopathology Sinoatrial Node / pathology* |
| Chemical | |
Reg. No./Substance:
|
525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combined vasodilator therapy for chronic congestive heart failure.
Next Document: Mexiletine for control of drug-resistant ventricular tachycardia: clinical and electrophysiologic re...