Document Detail

Experimental studies of new embolizing material for portal vein embolization.
MedLine Citation:
PMID:  10919034     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Preoperative portal vein embolization induces hypertrophy of the future remnant liver and atrophy of the liver to be resected. This procedure has been used recently to avoid hepatic failure in extensive hepatic resection, but an adequate embolizing material has not been developed. This experimental study investigated the embolization effect of a newly devised embolizing material in dogs. METHODOLOGY: The left branch of the portal vein was embolized with an emulsion of polidocanol and gelatin sponge. We studied the changes in liver weight and biochemical data up to 8 weeks after embolization. Pathological examination of the embolized portal vein and radiological study of the embolizing effect were performed. RESULTS: Complete obstruction of the portal vein was maintained until 8 weeks after embolization. Sufficient hypertrophy of the non-embolized liver and atrophy of the embolized liver were obtained during this examination. No serious complication was observed. CONCLUSIONS: The mixture of polidocanol and gelatin sponge seems to ensure perfect portal embolization without recanalization. This embolizing material is suitable for portal embolization.
T Kaneko; A Nakao; H Takagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  47     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  790-4     Citation Subset:  IM    
Department of Surgery II, Faculty of Medicine, University of Nagoya, Japan.
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MeSH Terms
Atrophy / chemically induced
Embolization, Therapeutic / methods*
Hypertrophy / chemically induced
Liver / pathology
Organ Size
Polyethylene Glycols / therapeutic use*
Portal Vein*
Sclerosing Solutions / therapeutic use*
Reg. No./Substance:
0/Polyethylene Glycols; 0/Sclerosing Solutions; 9002-92-0/polidocanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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