Document Detail

Experimental studies on multiple-model predictive control for automated regulation of hemodynamic variables.
MedLine Citation:
PMID:  12669984     Owner:  NLM     Status:  MEDLINE    
A model-based control methodology was developed for automated regulation of mean arterial pressure and cardiac output in critical care subjects using inotropic and vasoactive drugs. The control algorithm used a multiple-model adaptive approach in a model predictive control framework to account for variability and explicitly handle drug rate constraints. The controller was experimentally evaluated on canines that were pharmacologically altered to exhibit symptoms of hypertension and depressed cardiac output. The controller performed better as compared to experiments on manual regulation of the hemodynamic variables. After the model bank was determined, mean arterial pressure was held within +/- 5 mm Hg 88.9% of the time with a standard deviation of 3.9 mm Hg. The cardiac output was held within +/- 1 l/min 96.1% of the time with a standard deviation of 0.5 l/min. The manual runs maintain mean arterial pressure only 82.3% of the time with a standard deviation of 5 mm Hg, and cardiac output 92.2% of the time with a standard deviation of 0.6 l/min.
Ramesh R Rao; Brian Aufderheide; B Wayne Bequette
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  50     ISSN:  0018-9294     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-02     Completed Date:  2003-05-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-88     Citation Subset:  IM    
Aspen Technology, Inc., Houston, TX 77077, USA.
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MeSH Terms
Blood Pressure / drug effects*
Cardiac Output / drug effects*
Cardiac Output, Low / drug therapy,  physiopathology
Cardiovascular Diseases / drug therapy*,  physiopathology
Dopamine / administration & dosage*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Hypertension / drug therapy,  physiopathology
Hypotension / drug therapy,  physiopathology
Infusion Pumps*
Infusions, Intravenous
Models, Cardiovascular*
Phenylephrine / administration & dosage*
Reproducibility of Results
Sensitivity and Specificity
Therapy, Computer-Assisted
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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