Document Detail


Experimental studies on the interrelationship between organs mediated by peptide YY: effect on splanchnic circulation and exocrine pancreas in dogs.
MedLine Citation:
PMID:  2130785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide YY (PYY) which is most likely to mediate colonic inhibition on digestive organs is also a potent vasoconstrictor. However, very little is known about the effect of circulating PYY on splanchnic blood flow. This study examined the effect of systemic administration of peptide YY on splanchnic circulation and exocrine pancreas in dogs. Under secretin stimulation, intravenous administration of PYY (0.1, 0.5, 1 and 2 micrograms/kg) significantly decreased pancreatic secretion volume and blood flows in the pancreatic tissue, the superior mesenteric artery and the celiac artery in a dose-related manner. At the same time, PYY increased mean blood pressure. Under secretin plus cholecystokinin stimulation, PYY (1 micrograms/kg) significantly inhibited pancreatic secretion volume and protein output. This study first shows that PYY potently reduces celiac arterial blood flow as well as intestinal blood flow at such doses that PYY inhibits exocrine pancreatic secretion.
Authors:
S Sumi; K Inoue; T Tobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nihon geka hokan. Archiv für japanische Chirurgie     Volume:  59     ISSN:  0003-9152     ISO Abbreviation:  Nihon Geka Hokan     Publication Date:  1990 May 
Date Detail:
Created Date:  1991-10-28     Completed Date:  1991-10-28     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  0421143     Medline TA:  Nihon Geka Hokan     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  224-33     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dogs
Female
Gastrointestinal Hormones / pharmacology*
Male
Pancreas / drug effects*,  secretion
Peptide YY
Peptides / pharmacology*
Splanchnic Circulation / drug effects*
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Peptides; 106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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