Document Detail

Experimental studies on fluosol DA administration in acute pancreatitis.
MedLine Citation:
PMID:  3179491     Owner:  NLM     Status:  MEDLINE    
Therapeutic use of the perfluorochemical emulsion, Fluosol DA, in acute pancreatitis was experimentally discussed in view of maintaining the local blood flow and oxygen supply in the pancreas to avoid further aggravation of pancreatitis. Acute pancreatitis was induced by deoxycholate injection into the pancreatic duct in adult mongrel dogs. Fluosol DA or 6% hydroxyethylstarch (HES) solution as control was transfused at 20 ml/kg/hour for the first 3 hours. Fluosol DA and HES solution improved the depressed cardiac output and pancreatic blood flow to normal levels. Compared with HES solution, Fluosol DA administration revealed a prominent increase in oxygen tension in the pancreatic tissue, which had decreased severely from onset of pancreatitis. Fluosol DA administration brought about better preservation of pancreatic mitochondrial functions. Despite no significant differences in blood levels of other pancreatic enzymes between Fluosol DA and HES solution, the sharp decrease in plasma postheparin phospholipase A2 suggested the protection of involved systemic organs including pancreas. Thus, maintaining pancreatic blood flow and increasing the oxygen transport by Fluosol DA administration seemed to play a positive role in inhibiting the progress of pancreatitis, though improvement of survival rate in acute pancreatitis was incomplete by Fluosol DA administration alone.
H Ohyanagi; O Ohashi; S Nakayama; M Yamamoto; S Okumura; Y Saitoh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials, artificial cells, and artificial organs     Volume:  16     ISSN:  0890-5533     ISO Abbreviation:  Biomater Artif Cells Artif Organs     Publication Date:  1988  
Date Detail:
Created Date:  1988-12-08     Completed Date:  1988-12-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802605     Medline TA:  Biomater Artif Cells Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-94     Citation Subset:  IM    
First Department of Surgery, School of Medicine, Kobe University, Japan.
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MeSH Terms
Acute Disease
Blood Substitutes
Cardiac Output
Deoxycholic Acid
Drug Combinations / therapeutic use
Fluorocarbons / therapeutic use*
Oxygen / blood
Pancreas / blood supply*,  enzymology
Pancreatitis / chemically induced,  physiopathology,  therapy*
Phospholipases A / blood
Phospholipases A2
Regional Blood Flow
Reg. No./Substance:
0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 75216-20-5/Fluosol-DA; 7782-44-7/Oxygen; 83-44-3/Deoxycholic Acid; EC 3.1.1.-/Phospholipases A; EC A2

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