Document Detail


Experimental studies on the antiviral agent famciclovir in Behçet's disease symptoms in ICR mice.
MedLine Citation:
PMID:  11736905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic oral aphthae, recurrent genital ulcers and uveitis are the three main manifestations of Behçet's disease (BD). The aetiopathogenesis of BD is still obscure, but herpes simplex virus (HSV) is one of the possible causal factors. Various kinds of drugs, including immunosuppressants and aciclovir have been used in treatment, but effectiveness is variable. OBJECTIVES: To demonstrate the efficacy of famciclovir, an antiviral compound that acts against HSV, varicella-zoster virus and hepatitis B virus, in a murine model of BD. METHODS: Using the HSV-induced BD mouse model, famciclovir was administered variously before and after inoculation or from the day of lesion occurrence, with appropriate controls. Ulceration of the mouth and genital skin and eye involvement were monitored. In addition, spleen cytokine expression was measured by polymerase chain reaction. RESULTS: Pretreatment and concurrent treatment did not affect the occurrence of BD, but treatment from the appearance of lesions was effective in improving BD and preventing recurrence. After famciclovir, interleukin 2 expression correlated with the recurrence of BD symptoms. CONCLUSIONS: This model suggests the possible role of immune response to viral infection in the development and activation of BD. The study provides a rationale for clinical trials of famciclovir in the human form of BD.
Authors:
S Sohn; D Bang; E S Lee; H J Kwon; S I Lee; S Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2001-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-804     Citation Subset:  IM    
Affiliation:
Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Suwon 442-721, Korea. sohnsh@madang.ajou.ac.kr
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MeSH Terms
Descriptor/Qualifier:
2-Aminopurine / analogs & derivatives*,  therapeutic use*
Animals
Antiviral Agents / therapeutic use*
Behcet Syndrome / drug therapy*,  immunology,  virology
Disease Models, Animal
Herpes Simplex / complications,  drug therapy
Interleukin-2 / metabolism
Mice
Mice, Inbred ICR
Prodrugs / therapeutic use*
Recurrence
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interleukin-2; 0/Prodrugs; 104227-87-4/famciclovir; 452-06-2/2-Aminopurine

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