| Experimental reproduction of ELEM. A study to determine the minimum toxic dose in ponies. | |
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MedLine Citation:
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PMID: 1513368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An experiment to gain insight into the minimum toxic dose of fumonisins was conducted by feeding ponies rations with known fumonisin concentrations. Naturally contaminated corn screenings (CS) were blended with pellets, corn, and molasses to formulate individual daily diets. One group of 4 ponies was fed a ration with fumonisin B1 (FB1) varying from less than 1 ppm to 22 ppm. A second group of 5 ponies was fed a ration at varying rates containing 8 ppm FB1 for 180 days. A panel of clinical chemistry parameters was evaluated twice weekly for both groups. One pony in the first group died of equine leukoencephalomalacia (ELEM) after 225 days of which the final 55 days' diet contained 22 ppm FB1. Approximately 9 days prior to death, this animal experienced elevated liver chemistry values. All 5 ponies in the second group experienced mild, transient, clinical signs; were euthanized at 180 days; and had mild, histopathological brain lesions. |
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Authors:
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T M Wilson; P F Ross; D L Owens; L G Rice; S A Green; S J Jenkins; H A Nelson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mycopathologia Volume: 117 ISSN: 0301-486X ISO Abbreviation: Mycopathologia Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-10-01 Completed Date: 1992-10-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505689 Medline TA: Mycopathologia Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Animal and Plant Health Inspection Service, National Veterinary Services Laboratories, USDA, Ames, IA 50010. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
/
analysis,
toxicity* Animals Brain / drug effects* Dose-Response Relationship, Drug Encephalomalacia / chemically induced, veterinary* Female Fumonisins* Horse Diseases / chemically induced* Horses Male Mycotoxins / administration & dosage, analysis, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Fumonisins; 0/Mycotoxins; 116355-83-0/fumonisin B1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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