Document Detail


Experimental replacement of the inferior vena cava: factors affecting patency.
MedLine Citation:
PMID:  6729703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate factors influencing graft patency in the venous system, we replaced the inferior vena cava (IVC) in 50 dogs. Expanded polytetrafluoroethylene ( ePTFE ) grafts with external support were implanted into 32 animals while autogenous, spiral jugular vein grafts were used to replace the IVC in 18 dogs. 111In-labeled autologous platelets and 125I-labeled canine fibrinogen were utilized to evaluate early thrombus formation. A distal arteriovenous (AV) fistula significantly (P less than 0.05) decreased both platelet and fibrin deposition on ePTFE grafts 3 hours following implantation. Patency rate of 12 ePTFE grafts with a temporary AV fistula was higher (75%) than that of grafts without fistula (25%) at 3 months (P less than 0.05). Spiral vein grafts with fistula showed 91% patency at 3 months; without fistula patency was only 67%. Venograms confirmed patency in five grafts followed up to 6 months. Antiplatelet therapy resulted in 100% patency in ePTFE and vein grafts during its administration, and vein grafts maintained patency after discontinuation of antiplatelet treatment. Spiral vein grafts showed no decrease in cross-sectional area at 3 months, while the cross-sectional area of ePTFE grafts decreased significantly (59%). Distal AV fistula decreases platelet and fibrin deposition leading to early occlusion in ePTFE grafts and produces excellent patency in spiral vein grafts. Antiplatelet therapy appears to further improve patency.
Authors:
P Gloviczki; L H Hollier; M K Dewanjee; V F Trastek; E A Hoffman; M P Kaye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery     Volume:  95     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-06-26     Completed Date:  1984-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  657-66     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriovenous Shunt, Surgical
Blood Vessel Prosthesis*
Dogs
Female
Heparin / administration & dosage
Ibuprofen / administration & dosage
Jugular Veins / transplantation*
Polytetrafluoroethylene
Postoperative Complications
Regional Blood Flow
Thrombosis / etiology
Vena Cava, Inferior / surgery*
Chemical
Reg. No./Substance:
15687-27-1/Ibuprofen; 9002-84-0/Polytetrafluoroethylene; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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