Document Detail

Experimental pulmonary fat embolism induced by injection of triolein in rats.
MedLine Citation:
PMID:  17698390     Owner:  NLM     Status:  MEDLINE    
The relationship between the volume of fat flowing in the bloodstream and the degree of pulmonary fat embolism has remained unclear. In this study, in order to examine whether the volume of fat particles in the bloodstream could be estimated from the degree of pulmonary fat embolism, 0.05, 0.1, 0.15, 0.2 and 0.25 ml of triolein were injected into male rats weighing 300-320 g, through the caudal vein. Consequently, it was noted that the severity of pulmonary fat embolism tended to gradually increase in proportion to the volume of injected triolein, with the severity of pulmonary fat embolism being significantly augmented by the injection of 0.2 and 0.25 ml of triolein, based on morphometric analysis. In application to human cases, about 60 ml of fat particles was estimated to flow into the bloodstream after the occurrence of a pelvic fracture. Moreover, the results of this study led to the hypothesis that the prognosis of pulmonary fat embolism is affected by the severity of preceding conditions which have caused fat embolism.
Hiromasa Inoue; Masakazu Hanagama; Munechika Kamiya; Kotaro Shinone; Masayuki Nata
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-14
Journal Detail:
Title:  Legal medicine (Tokyo, Japan)     Volume:  10     ISSN:  1344-6223     ISO Abbreviation:  Leg Med (Tokyo)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100889186     Medline TA:  Leg Med (Tokyo)     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Department of Forensic Medicine and Sciences, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan. <>
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MeSH Terms
Cerebrum / pathology
Dose-Response Relationship, Drug
Embolism, Fat / pathology*
Forensic Pathology
Injections, Intravenous
Kidney / pathology
Lung / pathology
Pulmonary Embolism / pathology*
Rats, Wistar
Severity of Illness Index
Triolein / administration & dosage*
Reg. No./Substance:

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