Document Detail


Experimental pulmonary eosinophilia in mice by Ascaris suum extract.
MedLine Citation:
PMID:  2339848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BL/6 mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral administration of cyclosporin, 50 mg/kg body weight, every other day significantly suppressed the pulmonary eosinophilia. Athymic C57BL/6-nu/nu mice failed to develop pulmonary eosinophilia. These data indicate that pulmonary eosinophilia caused by this parasite extract is T-cell-dependent. Genetically mast-cell-deficient (WB X C57BL/6)F1-W/WV (W/WV) mice developed marked eosinophilia in the BAL, which shows that mast cells are not necessary in the formation of eosinophilia in BAL in this model. C57BL/6, W/WV, and Balb-C mice that developed eosinophilia in the BAL also showed elevated total IgE levels and IgE titers against Asc in the sera. On the other hand, C57BL/6-nu/nu mice and IgE low-responder SJL mice, which developed little eosinophilia, did not show elevated total IgE levels and IgE titers against Asc in the sera. However, oral administration of cyclosporin, 50 mg/kg, which inhibited eosinophilia in the BAL in C57BL/6 mice, did not significantly inhibit the elevation of total IgE or IgE against Asc in the sera. This indicates that serum IgE production is not required for the formation of eosinophilia.
Authors:
M Nogami; M Suko; H Okudaira; T Miyamoto; J Shiga; M Ito; S Kasuya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  141     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-18     Completed Date:  1990-06-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1289-95     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascaris
Bronchoalveolar Lavage Fluid / cytology
Cyclosporins / pharmacology
Enzyme-Linked Immunosorbent Assay
Immunoglobulin E / analysis
Male
Mast Cells / physiology
Mice
Mice, Inbred C57BL
Mice, Nude
Pulmonary Eosinophilia / chemically induced,  immunology*
Rats
Rats, Inbred Strains
T-Lymphocytes / physiology
Tissue Extracts
Chemical
Reg. No./Substance:
0/Cyclosporins; 0/Tissue Extracts; 37341-29-0/Immunoglobulin E; 59787-61-0/cyclosporin C

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