Document Detail

Experimental pulmonary eosinophilia in mice by Ascaris suum extract.
MedLine Citation:
PMID:  2339848     Owner:  NLM     Status:  MEDLINE    
The transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BL/6 mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral administration of cyclosporin, 50 mg/kg body weight, every other day significantly suppressed the pulmonary eosinophilia. Athymic C57BL/6-nu/nu mice failed to develop pulmonary eosinophilia. These data indicate that pulmonary eosinophilia caused by this parasite extract is T-cell-dependent. Genetically mast-cell-deficient (WB X C57BL/6)F1-W/WV (W/WV) mice developed marked eosinophilia in the BAL, which shows that mast cells are not necessary in the formation of eosinophilia in BAL in this model. C57BL/6, W/WV, and Balb-C mice that developed eosinophilia in the BAL also showed elevated total IgE levels and IgE titers against Asc in the sera. On the other hand, C57BL/6-nu/nu mice and IgE low-responder SJL mice, which developed little eosinophilia, did not show elevated total IgE levels and IgE titers against Asc in the sera. However, oral administration of cyclosporin, 50 mg/kg, which inhibited eosinophilia in the BAL in C57BL/6 mice, did not significantly inhibit the elevation of total IgE or IgE against Asc in the sera. This indicates that serum IgE production is not required for the formation of eosinophilia.
M Nogami; M Suko; H Okudaira; T Miyamoto; J Shiga; M Ito; S Kasuya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  141     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-18     Completed Date:  1990-06-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1289-95     Citation Subset:  AIM; IM    
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology
Cyclosporins / pharmacology
Enzyme-Linked Immunosorbent Assay
Immunoglobulin E / analysis
Mast Cells / physiology
Mice, Inbred C57BL
Mice, Nude
Pulmonary Eosinophilia / chemically induced,  immunology*
Rats, Inbred Strains
T-Lymphocytes / physiology
Tissue Extracts
Reg. No./Substance:
0/Cyclosporins; 0/Tissue Extracts; 37341-29-0/Immunoglobulin E; 59787-61-0/cyclosporin C

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