Document Detail


Experimental production of portal hypertension in dogs by a whole liver compression.
MedLine Citation:
PMID:  6852438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of many attempts to produce an experimental model for studying the pathogenesis and the pathophysiology of portal hypertension and esophageal varices, satisfactory results have not been reported. Since most attempts involved multiple operations or complicated surgical maneuvers to achieve portal hypertension, experimental animals could not survive easily. This new procedure requires only a simple operation, so experimental animal survival is high. The portal venous pressure can be raised immediately by increasing intrahepatic vascular resistance. This is done by wrapping and compressing the whole liver with polypropylene mesh, which also prevents the development of hepatopetal collaterals. The experimental production of portal hypertension in fifteen dogs resulted in only one death. The remaining fourteen dogs were in good condition for nine weeks after the operation and were maintaining elevated ranges of portal pressure with an average of 326 mmH2O. Varying degrees of esophageal venous dilatation were evident. Based on the results, this newly developed method seems to be useful for studying the pathophysiology of the portal hypertension and esophageal varices.
Authors:
H Yamana; K Yatsuka; T Kakegawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  18     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Esophageal and Gastric Varices / etiology
Female
Hypertension, Portal / etiology*,  physiopathology
Liver / physiopathology*
Liver Circulation
Male
Methods
Portal System / physiology
Pressure
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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