| Experimental production of papillary muscle and mitral valve lesions by vagal manipulations in rabbits. | |
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MedLine Citation:
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PMID: 7087152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present paper describes peculiar lesions in papillary muscles and mitral valves produced by vagal manipulations. In the 109 rabbits killed one week after clipping or crushing of their cervical vagi, papillary muscle and mitral valve lesions were found in 53 (48.6%) and 52 (47.7%) hearts respectively. The lesions were identified by visible deposits of colloidal carbon which had been injected intravenously during the first 3 postoperative days. The left ventricular free wall, interventricular septum and right ventricle were free of carbon deposits. The papillary muscles involved were characterized by swelling and increased stiffness which corresponded to degeneration of the myocardial cells and interstitial fibrosis on microscopic observation. Hydroxyproline content of the papillary muscles involved was 1.4 times more than that of normal hearts, while there was no significant difference in hydroxyproline content of either interventricular septum or left ventricular free wall between the manipulated and the normal preparations. Heart murmurs were heard in 23 animals studied. Phonocardiograms revealed mid to late systolic murmurs with or without midsystolic click. These results indicate that the vagus nerve plays an important role in the pathogenesis of some forms of papillary muscle and mitral valve lesions. |
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Authors:
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K Imataka; N Takahashi; A Seki; J Fujii |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 46 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 362-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon / analysis Cardiomyopathies / etiology Chordae Tendineae / innervation Hydroxyproline / analysis Male Mitral Valve / innervation*, pathology Myocardium / analysis Papillary Muscles / innervation*, pathology Phonocardiography Rabbits Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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51-35-4/Hydroxyproline; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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