| Experimental porcine eperythrozoonosis: T-lymphocyte suppression and misdirected immune responses. | |
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MedLine Citation:
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PMID: 3874572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune responses and hematologic alterations were investigated in splenectomized pigs after IM inoculation with Eperythrozoon suis. Early hematologic alterations were massive parasitism of RBC, severe hypoglycemia, moderate bilirubinemia, and mild anemia; later findings included severe anemia, minimal parasitism of RBC, spontaneous agglutination of RBC at 25 C and 4 C which was reversible at 37 C, transient thrombocytopenia, and mild bilirubinemia. The humoral immune responses consisting of a transitory hyperglobulinemia and increase of indirect hemagglutination (IHA) titers against E suis were attributed to immunoglobulin M cold agglutinins. Cell-mediated immune responses, measured by phytohemagglutinin- and pokeweed mitogen-induced lymphocyte blastogenesis, were reduced after massive parasitemia. Blastogenesis induced by Escherichia coli lipopolysaccharide mitogen was increased before the hyperglobulinemia and an increase in IHA titer. There was an increase in the uptake of [3H]thymidine by lymphocytes cultured without mitogens after the decline in total globulin concentration and IHA titer. |
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Authors:
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J F Zachary; A R Smith |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 46 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-08-05 Completed Date: 1985-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 821-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaplasmataceae Infections
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veterinary* Animals Antibodies, Bacterial / biosynthesis Blood Cell Count / veterinary Hemagglutination Tests / veterinary Hematocrit / veterinary Lymphocyte Activation Microscopy, Electron Mycoplasma / immunology Mycoplasma Infections / blood, immunology, veterinary* Swine Swine Diseases / blood, immunology* T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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