| Experimental pancreatitis in the rat. Changes in pulmonary phospholipids during sodium taurocholate-induced acute pancreatitis. | |
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MedLine Citation:
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PMID: 6856989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute haemorrhagic pancreatitis was induced in rats by injecting aqueous solution of sodium taurocholate into the common biliopancreatic duct. Lecithin and lysolecithin were separated from pulmonary homogenate by thin layer chromatography and quantified by phosphorus determination. The ratio of lysolecithin to lecithin increased after the sodium taurocholate injection as well as after i.v. administration of porcine pancreatic phospholipase A2. It was concluded that phospholipase A2, released from pancreatic acinar cells into blood, may convert pulmonary lecithin into lysolecithin during acute pancreatitis. Destruction of pulmonary surfactant may contribute to the development of the adult respiratory distress syndrome as seen in patients suffering from severe acute pancreatitis. |
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Authors:
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H J Aho; R A Ahola; A M Tolvanen; T J Nevalainen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Volume: 182 ISSN: 0300-9130 ISO Abbreviation: Res Exp Med (Berl) Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-15 Completed Date: 1983-07-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0324736 Medline TA: Res Exp Med (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 79-84 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Female Lung / analysis* Lysophosphatidylcholines / analysis Pancreatitis / chemically induced, metabolism* Phosphatidylcholines / analysis Phospholipases A / toxicity Phospholipases A2 Phospholipids / analysis* Rats Rats, Inbred Strains Taurocholic Acid |
| Chemical | |
Reg. No./Substance:
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0/Lysophosphatidylcholines; 0/Phosphatidylcholines; 0/Phospholipids; 81-24-3/Taurocholic Acid; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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