Document Detail

Experimental pancreatitis in the rat. Changes in pulmonary phospholipids during sodium taurocholate-induced acute pancreatitis.
MedLine Citation:
PMID:  6856989     Owner:  NLM     Status:  MEDLINE    
Acute haemorrhagic pancreatitis was induced in rats by injecting aqueous solution of sodium taurocholate into the common biliopancreatic duct. Lecithin and lysolecithin were separated from pulmonary homogenate by thin layer chromatography and quantified by phosphorus determination. The ratio of lysolecithin to lecithin increased after the sodium taurocholate injection as well as after i.v. administration of porcine pancreatic phospholipase A2. It was concluded that phospholipase A2, released from pancreatic acinar cells into blood, may convert pulmonary lecithin into lysolecithin during acute pancreatitis. Destruction of pulmonary surfactant may contribute to the development of the adult respiratory distress syndrome as seen in patients suffering from severe acute pancreatitis.
H J Aho; R A Ahola; A M Tolvanen; T J Nevalainen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  182     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1983  
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Lung / analysis*
Lysophosphatidylcholines / analysis
Pancreatitis / chemically induced,  metabolism*
Phosphatidylcholines / analysis
Phospholipases A / toxicity
Phospholipases A2
Phospholipids / analysis*
Rats, Inbred Strains
Taurocholic Acid
Reg. No./Substance:
0/Lysophosphatidylcholines; 0/Phosphatidylcholines; 0/Phospholipids; 81-24-3/Taurocholic Acid; EC 3.1.1.-/Phospholipases A; EC A2

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