Document Detail


Experimental pancreatitis: Effect of plasma and dextran on pancreatic blood flow.
MedLine Citation:
PMID:  684623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of extensive investigations, many aspects of the hemodynamic changes occurring in acute pancreatitis are understood poorly. A dog model was established in which continuous measurements of pancreatic arterial blood flow, cardiac output, and mean arterial blood pressure were made using electromagnetic flow probes and a pressure transducer, respectively. Pancreatitis was induced and the animals were monitored for 3 hours. In addition, control animals (group I) without pancreatitis also were done. All animals 50 ml of saline in the first hours. Three methods of therapy then were instituted in the dogs with pancreatitis and their effects were recorded. group I 6 dogs control animals no pancreatitis saline 50 ml/hr group II 10 dogs saline 50 ml/hr group III 6 dogs plasma 15 ml/kg over 45 min then saline 50 ml/hr group IV 10 dogs saline 50 ml and 1.5 ml/kg of dextran 40/hr These results confirm the observations made previously using a transillumination technique--that the pancreatic circulation rapidly reduces in acute pancreatitis. Administration of plasma produced a significant (P less than 0.05) but transient increase in the cardiac output and pancreatic blood flow; however, the blood pressure remained low. Dextran 40 minimally increased cardiac output, but it significantly improved the blood pressure and maintained the pancreatic blood flow. Low-dose, low-molecular weight dextran 40 appears to help to maintain pancreatic blood flow in acute pancreatitis. The possible mechanisms concerning the made of action of dextran 40 will be discussed.
Authors:
L A Donaldson; R W Williams; W G Schenk
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  84     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiopathology
Blood Circulation / drug effects
Blood Pressure / drug effects
Cardiac Output / drug effects
Dextrans / therapeutic use*
Dogs
Hemodynamics
Pancreas / blood supply*
Pancreatitis / physiopathology*,  therapy
Plasmapheresis*
Sodium Chloride / therapeutic use
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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