| Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. | |
MedLine Citation:
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PMID: 9620515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IMPLICATIONS: In this study, we examined ibuprofen, a widely used nonsteroidal antiinflammatory drug, for its ability to reduce experimental pain. We found that it had such properties in healthy young male subjects but not in young female subjects. This is a paradox because many of the painful conditions for which nonsteroidal antiinflammatory drugs are used (e.g., rheumatoid arthritis) occur more often in women. |
Authors:
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J S Walker; J J Carmody |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 86 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-06-19 Completed Date: 1998-06-19 Revised Date: 2014-07-29 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1257-62 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analgesics / pharmacokinetics, therapeutic use* Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics, therapeutic use* Case-Control Studies Cross-Over Studies Double-Blind Method Ear, External / innervation Electric Stimulation Female Humans Ibuprofen / pharmacokinetics, therapeutic use* Linear Models Male Nociceptors / drug effects, physiology* Pain / physiopathology*, prevention & control Pain Threshold / drug effects, physiology Placebos Sex Characteristics* Skin / innervation |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Placebos; WK2XYI10QM/Ibuprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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