Document Detail


Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen.
MedLine Citation:
PMID:  9620515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: In this study, we examined ibuprofen, a widely used nonsteroidal antiinflammatory drug, for its ability to reduce experimental pain. We found that it had such properties in healthy young male subjects but not in young female subjects. This is a paradox because many of the painful conditions for which nonsteroidal antiinflammatory drugs are used (e.g., rheumatoid arthritis) occur more often in women.
Authors:
J S Walker; J J Carmody
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  86     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1257-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analgesics / pharmacokinetics,  therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics,  therapeutic use*
Case-Control Studies
Cross-Over Studies
Double-Blind Method
Ear, External / innervation
Electric Stimulation
Female
Humans
Ibuprofen / pharmacokinetics,  therapeutic use*
Linear Models
Male
Nociceptors / drug effects,  physiology*
Pain / physiopathology*,  prevention & control
Pain Threshold / drug effects,  physiology
Placebos
Sex Characteristics*
Skin / innervation
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Placebos; WK2XYI10QM/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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