Document Detail


Experimental osteoarthritis in the rabbit: comparison of different periods of repeated immobilization.
MedLine Citation:
PMID:  7090758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to compare the degree of osteoarthritis caused by different periods of repeated immobilization and mobilization. Existing knowledge of the pathogenic factors causing osteoarthritis is deficient, but it is well known that long-term immobilization produces degenerative joint changes. In this experimental study it is shown that short repetitive periods of immobilization also induce osteoarthritis. The results can be summarized as follows: immobilization, periodic or continuous, over more than 30 days will lead to progressive osteoarthritis. The range of motion after periodic immobilization depends more on the total immobilization time than on the duration of either the immobilization or mobilization periods. Even an immobilization period of 4 days had a cumulative effect in producing osteoarthritis. An interval of 4 weeks between immobilization periods did not prevent immobilization from causing osteoarthritis. It can be assumed that all situations which lead to the immobilization of a joint can cause osteoarthritis changes. Radiology, photography, and histology all showed some degree of degenerative changes also in the contralateral non-immobilized knee.
Authors:
T Videman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  53     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  339-47     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Femur / pathology
Immobilization*
Knee / pathology,  physiopathology,  radiography
Knee Joint / physiopathology,  radiography
Osteoarthritis / etiology*,  physiopathology,  radiography
Photography
Rabbits
Tibia / pathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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