| Experimental optimization of flow distributors for pressure-driven separations and reactions in flat-rectangular microchannels. | |
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MedLine Citation:
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PMID: 21175164 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report on the results of an experimental study established to optimize the design of microfabricated flow distributors for use in pressure-driven separations and reactions in flat-rectangular channels. For this purpose, the performance of a wide variety of possible flow distributor designs etched in glass/silicon wafers was compared, using CCD camera detection to study the shape and variance of the bands eluting from them. The best performance was obtained with radially interconnected distributors with a diverging inlet section and filled with diamond-shaped pillars, oriented perpendicular to the main flow direction and with a high transversal over axial aspect ratio. It was found that the best distributor designs start with a diverging section containing some 10-12 subsequent rows of high aspect ratio pillars (with a transversal width making up 10-15% of the final channel width) and with a divergence angle selected such that the sloped side-walls run parallel with the sides of the diamond-shaped pillars. After this zone, one or more regions with pillars with a smaller aspect ratio should be provided to increase the number of exit points. To prevent the formation of dead zones in these subsequent zones, so-called distributor wedges can be used to prevent the formation of any dead zones in the wake of the large aspect ratio pillars of the preceding section. |
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Authors:
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Joris Vangelooven; Stefan Schlautman; Frederik Detobel; Han Gardeniers; Gert Desmet |
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Publication Detail:
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Type: Journal Article Date: 2010-12-22 |
Journal Detail:
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Title: Analytical chemistry Volume: 83 ISSN: 1520-6882 ISO Abbreviation: Anal. Chem. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: United States |
Other Details:
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Languages: eng Pagination: 467-77 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering (Transport Modelling & Analytical Separation Science-group), Vrije Universiteit Brussel, Brussels, Belgium, and MESA+ Research Institute, University of Twente, Enschede, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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