| Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. | |
| | |
MedLine Citation:
|
PMID: 21296565 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Mycotoxic nephropathy was induced in eighteen young pigs by mouldy diets containing 0.5ppm ochratoxin A (OTA) and/or 10ppm fumonisin B1 (FB1) for three months. While the most obvious damages provoked by OTA were seen in the kidneys as expressed by the strong degenerative changes in proximal tubules and fibrosis in kidneys, FB1 was found to induce an increase in permeability of vessels mainly in lung, brain, cerebellum or kidneys and slight to moderate degenerative changes in kidneys. Pathomorphological damages in pigs exposed to both mycotoxins simultaneously present a combination of the main lesions provoked by each mycotoxin alone being stronger in their expression. Biochemical investigations as expressed by the increase of serum creatinine, urea and enzyme activity of ASAT/ALAT and by the decrease of serum cholesterol, total protein, albumin and glucose were strongest in pigs exposed to both mycotoxins simultaneously as can be anticipated form the strongest lesions in the kidneys. Both mycotoxins and their combination were found to disturb powerfully humoral immune response in all experimental pigs as expressed by the strong decrease in antibody titer against Morbus Aujesky at days 21 and 35 after vaccination. Having in mind that the feed levels of the both mycotoxins as well as the exposure time and the pathological findings corresponded to those in some spontaneous cases of porcine nephropathy in Bulgaria and South Africa, it can be concluded that the same mycotoxins are involved in the observed field cases of that nephropathy. |
| | |
Authors:
|
Stoycho D Stoev; Dimitrina Gundasheva; Ivan Zarkov; Teodora Mircheva; Dimitrina Zapryanova; Stefan Denev; Yuri Mitev; Hristo Daskalov; Mike Dutton; Mulunda Mwanza; Yves-Jacques Schneider |
Related Documents
:
|
3351705 - Comparison of a lactose-free cereal-based formula and cow's milk in infants and childre... 15379915 - Effect of protein : energy ratio in milk replacers on growth performance of goat kids. 16772555 - Casein breakdown in terrincho ovine cheese: comparison with bovine cheese and with bovi... 20105515 - Invited review: technical solutions for analysis of milk constituents and abnormal milk. 2058575 - Specific types of colonic fermentation may raise low-density-lipoprotein-cholesterol co... 21645315 - Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-4 |
Journal Detail:
|
Title: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie Volume: - ISSN: 1618-1433 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Medical Exposure to Radiation and Thyroid Cancer.
Next Document: Nuclear pore complex-a coat specifically tailored for the nuclear envelope.