Document Detail

Experimental models of ventricular tachycardia and fibrillation caused by ischemia and infarction.
MedLine Citation:
PMID:  1728503     Owner:  NLM     Status:  MEDLINE    
Experimental animal models of ventricular arrhythmias have been developed to elucidate mechanisms of arrhythmogenesis in humans. Studies of animal models have enabled the vulnerable period of the ventricles to be discovered and characterized and should eventually lead to improved techniques of defibrillation. Animal models of ischemic heart disease and myocardial infarction have also helped investigators elucidate the mechanisms of arrhythmias occurring at each stage of infarct development and healing. Data obtained from the experimental studies have been shown to apply to the clinical situation.
A L Wit; M J Janse
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation     Volume:  85     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I32-42     Citation Subset:  AIM; IM    
Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, N.Y. 10032.
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MeSH Terms
Arrhythmias, Cardiac / etiology,  physiopathology
Coronary Disease / complications*
Disease Models, Animal
Myocardial Infarction / complications*
Reference Values
Tachycardia / etiology*
Ventricular Fibrillation / etiology*
Grant Support

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