Document Detail


Experimental models to investigate the function of dendritic cell subsets: challenges and implications.
MedLine Citation:
PMID:  23286941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The dendritic cell (DC) lineage is remarkably heterogeneous. It has been postulated that specialized DC subsets have evolved in order to select and support the multitude of possible T cell differentiation pathways. However, defining the function of individual DC subsets has proven remarkably difficult, and DC subset control of key T cell fates such as tolerance, T helper cell commitment and regulatory T cell induction is still not well understood. While the difficulty in assigning unique functions to particular DC subsets may be due to sharing of functions, it may also reflect a lack of appropriate physiological in-vivo models for studying DC function. In this paper we review the limitations associated with many of the current DC models and highlight some of the underlying difficulties involved in studying the function of murine DC subsets.
Authors:
D G Hancock; T V Guy; E Shklovskaya; B Fazekas de St Groth
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-03-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
Cell Communication
Cell Differentiation
Cell Lineage
Dendritic Cells / immunology*
Humans
Immune Tolerance
Lymphocyte Activation*
Mice
Models, Animal*
T-Lymphocyte Subsets / immunology*
T-Lymphocytes / immunology*
Comments/Corrections

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