Document Detail

Experimental models of heart failure.
MedLine Citation:
PMID:  3159477     Owner:  NLM     Status:  MEDLINE    
Experimental models of heart failure can be used to address specific questions not easily answered in patients, but no single model can reproduce exactly any of the clinical syndromes of heart failure since these are dominated by fatigue and breathlessness. Heart failure may be induced experimentally by pressure loading, volume loading, myocardial infarction, or by the creation of other disease states within the myocardium. Pressure loading may be especially useful in the study of ventricular hypertrophy, cellular derangements and vascular changes. Volume loading may be useful when examining the pathogenesis of hormone and electrolyte disturbances. Models of myocardial infarction or destruction are likely to be the most suitable for assessing novel therapy provided that peripheral reflexes are maintained. Experimental cardiomyopathy can provide an important means of identifying pathological subcellular mechanisms. They may be of use in the evaluation of vasodilator drugs but caution should be exercised in the study of inotropic agents. Any one model may be useful if it permits study of a single factor or variable in isolation or at a time when information is not obtainable from patients. For greatest clinical relevance, studies should be made in conscious animals with intact reflexes.
H J Smith; A Nuttall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  19     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-08-20     Completed Date:  1985-08-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  IM    
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MeSH Terms
Barbiturates / toxicity
Blood Pressure
Blood Volume
Cardiomyopathy, Dilated / chemically induced
Disease Models, Animal*
Furazolidone / toxicity
Heart Diseases / physiopathology*
Myocardial Infarction / physiopathology
Reg. No./Substance:
0/Barbiturates; 67-45-8/Furazolidone; 67-52-7/barbituric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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