| Experimental models of complete heart block. | |
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MedLine Citation:
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PMID: 811214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methods of creating experimental complete heart block developed since 1883 are reviewed in detail. The three most commonly used techniques at present are: (I) Thoracotomy, atriotomy and ligation of the A-V bundle. (II) Thoracotomy and injection of a chemical into the A-V node or bundle. (III) Injection of a chemical through a transvenous catheter into the node or bundle. The results in different species, complications, and variations in procedure are discussed. The bibliography provides a comprehensive index of work performed in animals with experimental complete heart block. We produced complete heart block in sixteen pigs but subsequently eleven died during Stokes-Adams attacks. Pigs have not been used previously as models of heart block for experimental purposes and prophylactic pacing appears mandatory in this species. |
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Authors:
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E K Weir; I F McMurtry; R F Grover |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Basic research in cardiology Volume: 70 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1975 Jul-Aug |
Date Detail:
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Created Date: 1976-01-23 Completed Date: 1976-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 446-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adams-Stokes Syndrome
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mortality Animals Atrioventricular Node / drug effects, surgery Bundle of His / drug effects, surgery Cats Disease Models, Animal* Dogs Formaldehyde / adverse effects Haplorhini Heart Atria / surgery Heart Block / chemically induced, physiopathology* Heart Rate / drug effects Heart Septum / surgery Humans Ligation Rabbits Rats Swine |
| Chemical | |
Reg. No./Substance:
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50-00-0/Formaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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