Document Detail

Experimental model of chronic limb lymphedema and determination of lymphatic and venous pressures in normal and lymphedematous limbs.
MedLine Citation:
PMID:  4083729     Owner:  NLM     Status:  MEDLINE    
Experimental studies on chronic lymphedema of the extremities were performed using dogs, and an improved technique after the method of Danese in the preparation of chronic limb lymphedema is described. The incidence of chronic lymphedema in this model was 81.8%, whereas with Danese's method, it was only 66.7%. In addition, the measurement of lymphatic and venous pressure was studied in experimental animals. In the normal limb, the lymphatic pressure was always lower than the venous pressure, while in the chronic lymphedematous limb, the lymphatic pressure was higher than the venous pressure. Thus, after a lymphaticovenous anastomosis, a pressure gradient reversal exists between the two sides of the anastomosis. Although the high lymphatic pressure gradually dropped as the anastomosis became patent, ultimately the venous pressure was often higher than the lymphatic pressure. A venous back flow can be ensured by the anastomosis and the resulting thrombosis, which obstructs the lymphaticovenous anastomosis, is inevitable.
L Y Han; T S Chang; W Y Hwang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  15     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-12     Completed Date:  1986-02-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-12     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Disease Models, Animal
Lymphatic System / physiopathology*
Lymphedema / etiology,  physiopathology*
Thrombosis / etiology
Venous Pressure

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