Document Detail


Experimental leprosy in rhesus monkeys: transmission, susceptibility, clinical and immunological findings.
MedLine Citation:
PMID:  9805879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 46 Rhesus monkeys (RM) was inoculated with Mycobacterium leprae (ML) and followed clinically and immunologically for extended periods. Twenty-one (45.7%) of the RM developed leprosy spanning the known leprosy spectrum, with six of 21 (28.6%) having disease in the borderline lepromatous to lepromatous area of the spectrum. RM with paucibacillary forms of leprosy produced predominantly IgG anti-phenolic glycolipid (PGL-I) antibodies and positive lepromin skin test and/or in vitro blastogenesis responses; IgM anti-PGL-I predominated in animals with BB-LL leprosy and correlated with negative immune responses to lepromin. IgG anti-PGL-I antibodies persisted in a number of RM for several years without histopathological evidence of leprosy, suggesting possible persisting subclinical infection. The data show that RM are a valuable model for the study of leprosy. Eleven of the 46 RM were inoculated with ML from sources infected with simian immunodeficiency virus (SIV), the monkey counterpart to the human immunodeficiency virus (HIV). The possible effect of SIV on the clinical outcome of ML infection could not be determined due to insufficient numbers of animals to yield statistically significant results.
Authors:
B J Gormus; K Xu; G B Baskin; L N Martin; R P Bohm; J L Blanchard; P A Mack; M S Ratterree; W M Meyers; G P Walsh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Leprosy review     Volume:  69     ISSN:  0305-7518     ISO Abbreviation:  Lepr Rev     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-10     Completed Date:  1998-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0243711     Medline TA:  Lepr Rev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  235-45     Citation Subset:  IM; X    
Affiliation:
Department of Microbiology, Pathology, Tulane Regional Primate Research Center, Covington, LA 70433, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / analysis*
Disease Models, Animal
Disease Susceptibility
Enzyme-Linked Immunosorbent Assay
Leprosy / immunology*,  transmission*
Macaca mulatta
Mycobacterium leprae / immunology*
Sensitivity and Specificity
Skin Tests
Grant Support
ID/Acronym/Agency:
A1-19302//PHS HHS; RR-00164/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

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