Document Detail

Experimental joint trauma: synovial response to blunt trauma and inflammatory reaction to intraarticular injection of fat.
MedLine Citation:
PMID:  7288755     Owner:  NLM     Status:  MEDLINE    
Blunt trauma to knee joints of dogs produces clear usually non-bloody synovial effusions with prominent fat globules. Increased vascular permeability of synovial membrane in areas not directly traumatized can be shown by leakage of intravenously-injected carbon black. To see whether fat released from synovium into the joint might contribute to a low grade inflammation and altered vascular permeability we also injected intraarticular autologous fat and demonstrated its phagocytosis by exudate cells and induction of definite inflammation. These effects of trauma in dogs which closely resemble some human injuries might be a model for evaluating conservative treatment of joint trauma.
A Weinberger; H R Schumacher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  8     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:    1981 May-Jun
Date Detail:
Created Date:  1981-12-22     Completed Date:  1981-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  380-9     Citation Subset:  IM    
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MeSH Terms
Fat Emulsions, Intravenous / administration & dosage*
Injections, Intra-Articular
Knee Injuries / physiopathology*
Microscopy, Electron
Synovial Fluid / physiopathology*
Synovial Membrane / physiopathology*,  ultrastructure
Synovitis / chemically induced*,  pathology,  radiography
Wounds, Nonpenetrating*
Reg. No./Substance:
0/Fat Emulsions, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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