| Experimental investigation of pulsatility effect on the deformability and hemolysis of blood cells. | |
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MedLine Citation:
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PMID: 20420600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we investigated the differences between pulsatile cardiopulmonary bypass (CPB) procedure and nonpulsatile CPB procedure in terms of their effects on hemolysis and deformability of red blood cells (RBCs) under various shear stress conditions. In order to research the effects on hemolysis and deformability, four parameters--free hemoglobin (fHb) concentration, normalized index of hemolysis (NIH), deformability index (DI) of RBCs, and elongation index of RBCs--have been deeply investigated. For these investigations, two randomly assigned adult mongrel dog groups-nonpulsatile group (NP, n = 6) and pulsatile group (P, n = 6)--were examined. According to our results, both types of perfusion did not show any statistical differences in terms of the concentrations of fHb as well as NIH. In addition, there were no significant differences in RBC deformability between perfusion types within an operation time of 3 h. Therefore, our studies suggest that pulsatile perfusion has no significant difference from nonpulsatile perfusion in terms of hemolysis and deformability of RBCs. |
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Authors:
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Yang Jun Kang; Myoung Gon Kim; Kuk Hui Son; Choon Hak Lim; Ho Sung Son; Sang Youl Yoon; Hyuk Sang Kwon; Sung Yang |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: E103-9 Citation Subset: IM |
Affiliation:
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Department of Mechatronics, Gwangju Institute of Science and Technology, Buk-gu, Gwangju, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass / adverse effects*, methods* Dogs Erythrocyte Deformability* Erythrocytes / cytology* Hemolysis* Image Processing, Computer-Assisted Pulsatile Flow Random Allocation Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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