| Experimental intrauterine Ureaplasma infection in sheep. | |
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MedLine Citation:
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PMID: 15846199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Prenatal Ureaplasma spp exposure is associated with preterm birth and modulates the neonates' susceptibility to respiratory distress syndrome and bronchopulmonary dysplasia. We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development. STUDY DESIGN: Pregnant ewes bearing singleton fetuses were given an intra-amniotic injection of 20 x 10 6 CFUs of U parvum (serovar 3) or vehicle, either 1, 3, 6, or 10 weeks before the delivery of preterm lambs at 124 days of gestation (n = 4-10 per group) for evaluation of inflammation and fetal lung maturation. RESULTS: Ureaplasmas were recovered from amniotic and fetal lung fluids after intra-amniotic injection. Body weight and umbilical arterial pH were reduced by Ureaplasma exposure for 10 weeks ( P < .05). Ureaplasmas caused progressive lung inflammation and improvements in lung function that were associated with increased surfactant lipids (control, 0.13 +/- 0.02 micromol/kg; 10 weeks of Ureaplasma exposure, 7.43 +/- 3.0 micromol/kg; P < .001) and surfactant protein messenger RNA expression. CONCLUSION: Long-term exposure to ureaplasmas in amniotic fluid alters ovine fetal development. |
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Authors:
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Timothy J M Moss; Ilias Nitsos; Machiko Ikegami; Alan H Jobe; John P Newnham |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-22 Completed Date: 2005-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1179-86 Citation Subset: AIM; IM |
Affiliation:
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School of Women's and Infants' Health, The University of Western Australia, Perth, Australia. tmoss@cyllene.uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Disease Models, Animal Female Fetal Development / physiology* Fetal Organ Maturity Lung / embryology* Pregnancy Pregnancy, Animal Premature Birth* Random Allocation Reference Values Risk Factors Sheep, Domestic Survival Rate Time Factors Ureaplasma Infections / complications*, mortality |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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