Document Detail

Experimental intrauterine Ureaplasma infection in sheep.
MedLine Citation:
PMID:  15846199     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Prenatal Ureaplasma spp exposure is associated with preterm birth and modulates the neonates' susceptibility to respiratory distress syndrome and bronchopulmonary dysplasia. We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development. STUDY DESIGN: Pregnant ewes bearing singleton fetuses were given an intra-amniotic injection of 20 x 10 6 CFUs of U parvum (serovar 3) or vehicle, either 1, 3, 6, or 10 weeks before the delivery of preterm lambs at 124 days of gestation (n = 4-10 per group) for evaluation of inflammation and fetal lung maturation. RESULTS: Ureaplasmas were recovered from amniotic and fetal lung fluids after intra-amniotic injection. Body weight and umbilical arterial pH were reduced by Ureaplasma exposure for 10 weeks ( P < .05). Ureaplasmas caused progressive lung inflammation and improvements in lung function that were associated with increased surfactant lipids (control, 0.13 +/- 0.02 micromol/kg; 10 weeks of Ureaplasma exposure, 7.43 +/- 3.0 micromol/kg; P < .001) and surfactant protein messenger RNA expression. CONCLUSION: Long-term exposure to ureaplasmas in amniotic fluid alters ovine fetal development.
Timothy J M Moss; Ilias Nitsos; Machiko Ikegami; Alan H Jobe; John P Newnham
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1179-86     Citation Subset:  AIM; IM    
School of Women's and Infants' Health, The University of Western Australia, Perth, Australia.
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MeSH Terms
Analysis of Variance
Disease Models, Animal
Fetal Development / physiology*
Fetal Organ Maturity
Lung / embryology*
Pregnancy, Animal
Premature Birth*
Random Allocation
Reference Values
Risk Factors
Sheep, Domestic
Survival Rate
Time Factors
Ureaplasma Infections / complications*,  mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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