Document Detail

Experimental infection with Giardia lamblia in rats.
MedLine Citation:
PMID:  7069229     Owner:  NLM     Status:  MEDLINE    
Sprague-Dawley rats were orally inoculated with Giardia lamblia cysts. Infection was documented using microscopic examination of feces, counterimmunoelectrophoresis (CIE) of feces for G. lamblia antigen, and intestinal biopsy. After inoculation with 150 cysts, 100% of the rats became infected. CIE and intestinal biopsy detected infection on days 2-3 after inoculation. Results of microscopic examinations were variable, but cysts were observed as early as day 4. CIE and intestinal biopsy were comparable in detecting infection. The infection rate peaked at day 7 and remained high until day 20. Spontaneous resolution of infection occurred after 28-42 days in 96% of the rats. Cysts stored in liquefied feces at 4 C demonstrated a gradual decline of infectivity but remained infective for one year.
J C Craft
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  145     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antigens / analysis
Disease Models, Animal*
Feces / parasitology
Giardia / growth & development,  immunology,  isolation & purification
Giardiasis / parasitology*
Intestine, Small / parasitology
Rats, Inbred Strains
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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