Document Detail

Experimental infection of suckling mice with a host range mutant of Junin virus.
MedLine Citation:
PMID:  1658215     Owner:  NLM     Status:  MEDLINE    
Experimental infection of three mouse strains with a non-pathogenic mutant of Junin virus named Cl67 was compared with respect to the parental XJCl3 strain. After intracerebral (ic) or intraperitoneal inoculation, XJCl3 was highly virulent for 2 day-old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative Cl67 was attenuated. Survival of the Cl67-infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of Cl67 for suckling mice is independent of the mouse strain and the route of viral entry. When Cl67 was preinoculated ic 10 days before the challenge inoculation with XJCl3 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post-infection, an interference mechanism is postulated as a mechanism of protection of the mice.
L A Scolaro; S E Mersich; E B Damonte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  34     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-12     Completed Date:  1991-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
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MeSH Terms
Antibodies, Viral / blood
Arenaviruses, New World / genetics,  growth & development,  immunology,  pathogenicity*
Disease Models, Animal
Hemorrhagic Fever, American / immunology,  microbiology*,  prevention & control
Mice, Inbred Strains
Mutation / genetics
Neutralization Tests
Plaque Assay
Vero Cells
Virulence / genetics
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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